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While family history of vascular disease is associated with the prevalence of coronary artery disease (CAD) and cerebrovascular disease (CVD), its association with peripheral artery disease (PAD) is less certain. Furthermore, the precise association between type of family history and PAD is unknown.
2.8 million US adults underwent ankle brachial index screening and self–reported demographics, risk factors and family history in a vascular screening program. PAD was defined as ABI <0.9. Family history of PAD (surgery or procedure to improve blood flow to the legs), CAD (heart attack or coronary revascularization), and CVD (stroke or transient ischemic attack) in a first degree relative before age 60 was collected. Multivariate logistic regression analysis was used to estimate odds of PAD.
Subjects with PAD were more likely to have a family history of PAD (4.6% vs 2.8%, p < 0.001), CAD (20.3% vs 16.3%, p < 0.001), and CVD (11.6% vs 8.9%, p < 0.001), than those without PAD. After multivariate adjustment, family history of PAD was associated with a 52% increase in PAD prevalence, compared to a modest 9% and 5% increase in PAD for family history of CAD and CVD, respectively (Table 1).
In a very large population based study, family history of PAD was an independent risk factor for PAD prevalence. While family history of CAD or CVD was statistically associated with PAD, the strength of association was weak, highlighting the importance of family history questions specific for PAD.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Atherosclerosis, Inflammation, Biomarkers and Outcomes: What's New?
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1124–162
- 2013 American College of Cardiology Foundation