Author + information
- Purushothaman K–Raman,
- Meerarani Purushothaman,
- Soojeong Kang,
- Elie Chemaly,
- Roger Hajjar,
- Valentin Fuster and
- Pedro Moreno
Resistin is reported as an independent inflammatory marker for coronary atherosclerosis in humans and associated with plaque progression in animal studies. However the role of resistin in human atherosclerosis has not been evaluated. We tested the hypothesis that lipid rich atheromatous plaques may be associated with increased resistin expression compared to lipid poor fibrotic plaques.
Twenty six human aortic plaques (13 Lipid rich AHA type VA vs.13 Lipid–poor AHA type VC) were studied. Resistin expression was quantified using immunohistochemistry and graded in 20 high power fields (40X) by stain intensity. AHA types (lipid–rich VA and fibrotic VC) were classified using H&E stain and microscopic planimetry used to evaluate lipid core area.
The resistin protein expression grade was significantly increased in lipid rich–atheromatous plaques (AHA type VA) compared to lipid poor–fibrotic plaques (AHA type VC) (p=0.001) (Figure). Similarly, lipid .core area (mm2) (p=0.0001) was increased. Linear regression analysis identified a correlation of resistin grade with lipid rich atheromatous plaques. (R= 0.617; p=0.001).
Increased expression of adipokine–resistin is seen in lipid–rich atheromatous plaques compared to lipid–poor fibrotic plaques. Further studies are needed to elucidate the mechanism underlying the increased expression of resistin in the lipid gruel. This may be useful as a therapeutic intervention in the prevention of plaque progression.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Vascular Medicine Basic: Atherogenesis
Abstract Category: 33. Vascular Medicine: Basic
Presentation Number: 1125M–170
- 2013 American College of Cardiology Foundation