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Family history of coronary artery disease (CAD) is a risk factor for developing CAD. However, little is known about family history as a risk factor for peripheral arterial disease (PAD). We investigated whether family history of atherosclerotic vascular disease (PAD or CAD) is associated with the presence of PAD.
Participants included 1331 patients with PAD (65±10 y, 63% men) and 1151 controls (60±7 y, 59% men) identified from non–invasive vascular and stress ECG laboratories, respectively. PAD was defined as a resting/post–exercise ankle–brachial index (ABI) ≤ 0.9, history of lower extremity revascularization, or having poorly compressible leg arteries. Controls were patients without history of PAD, CAD or cerebrovascular disease. Family history of PAD and CAD was obtained from a detailed self–administered questionnaire and was defined as having any first–degree relative with onset of PAD or CAD before age 65. Demographics, risk factors and comorbidities were ascertained from the electronic medical record based on ICD–9–CM codes, medication use and laboratory data. (Kullo et al. J Am Med Inform Assoc. 2010) Logistic regression analyses were used to evaluate the association of a family history of PAD or CAD with the presence of PAD.
Family history of PAD was present more often in PAD cases than in controls (12.1% vs. 2.9%). Family history of CAD was also more frequent in PAD cases than in controls (49.4% vs. 33.7%). In logistic regression analyses, a family history of PAD was associated with higher odds ratio (OR) (95% CI) of having PAD: 4.7 (3.2–6.9). The association remained significant after adjustment for age, sex, body mass index, smoking, diabetes, hypertension and dyslipidemia; OR (95% CI): 4.3 (2.8–6.8). Similarly, a family history of CAD was also associated with higher OR (95% CI) of having PAD: 1.9 (1.6–2.3). This association remained significant after adjustment for above mentioned covariates; OR (95% CI): 1.7 (1.4–2.1).
A family history of PAD or CAD is associated with the presence of PAD independent of conventional risk factors. These results indicate that genetic and/or shared environmental factors are important in the development of PAD.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Classic and Novel Cardiovascular Risk Predictors and Impact
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167M–168
- 2013 American College of Cardiology Foundation