Author + information
- Julia Collin,
- Mario Goessl,
- Yoshiki Matsuo,
- Andreas Flammer,
- Darrell Loeffler,
- Ryan Lennon,
- Sundeep Khosla,
- Robert Simari,
- Daniel Spoon,
- Lilach Lerman and
- Amir Lerman
Myeloid calcifying cells (from monocyte/macrophage linage expressing Osteocalcin [OCN+]) were found to play a major role in diabetic carotid atherosclerosis. We hypothesized a link between CD14+/OCN+–cells and degree of coronary calcification using virtual histology–intravascular ultrasound (VH–IVUS).
Twenty–three patients with angiographically non–obstructive coronary artery disease underwent VH–IVUS in left coronary artery. Plaque volume and dense calcification (DC) were measured in total segment and the worst diseased segment (WS). Volume data was expressed as average area (mm3/mm) to compensate for different segment length. Simultaneous aortic and coronary sinus (CS) blood samples were taken for flow cytometry and net gradient calculation (Coronary blood flow × [number of aortic – CS cells]). Spearman's correlation was used.
Circulating CD14+/OCN+–cells correlated significantly with DC and plaque burden in the total analyzed segment (r=0.60, p<0.01 and r=0.58, p<0.01) and the WS (r=0.65, p<0.001 and r=0.67, p<0.001). CD14+/OCN+ net gradient correlated positively with DC (Figure 1) and plaque burden in the total analyzed segment (r=0.63, p<0.01 and r=0.48, p<0.05) and with DC in the WS (r=0.58, p<0.01).
The direct associations of DC and plaque burden with systemic levels and local retention of CD14+/OCN+–cells implicate these cells in pathological remodeling of the coronary circulation in patients with early coronary atherosclerosis.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Angiogenesis and Vascular Injury
Abstract Category: 33. Vascular Medicine: Basic
Presentation Number: 1254–171
- 2013 American College of Cardiology Foundation