Author + information
- Jin-Sok Yu,
- Chul-Soo Park,
- Yun-Seok Choi,
- Ju-Youn Kim,
- Woo-Baek Chung,
- Man-Young Lee,
- Yong-Seok Oh,
- Ho-Joong Youn,
- Wook-Sung Chung and
- Sang-Hyun Ihm
The white blood cell and neutrophil count has been considered as risk factors for coronary artery disease (CAD), while the data of monocytes’ role in CAD is rare. Monocyte can be classified by CD14 and CD16 surface molecule and each monocyte subset has different functional characteristics in atherosclerosis. Therefore, we hypothesized that monocyte subset might be associated with CAD.
We enrolled 208 consecutive patients (mean age; 63±11 years) with stable (SAP) or unstable (UAP) angina and control patients whose coronary angiogram showed no significant stenosis. We measured each monocyte subset using flow cytometry.
1. The percent of CD14++CD16+ monocyte was lower in unstable angina compared to control (4.8±5.1 vs 9.1±6.4 %, p<0.01) or stable angina patients (4.8±5.1 vs 7.5±7.4 %, p<0.01). 2. The percent of CD14++CD16- monocyte was higher in unstable angina compared to control (72.4±13.8 vs 53.4±12.2%, p<0.01) or stable angina patients (72.4±13.8 vs 61.0±13.4 %, p<0.01) (Figure 1). 3. Among the stable angina patients, the percent of CD14++CD16- monocyte was lower in statin treated patients than non-statin treated patients (58.8±14.8 vs 64.0±11.4 %, p<0.01).
The elevated CD14++CD16- monocyte subset might be a risk factor coronary artery disease and also be involved in plaque vulnerability.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Acute Coronary Syndromes: Basic I
Abstract Category: 2. Acute Coronary Syndromes: Basic
Presentation Number: 1127-189
- 2013 American College of Cardiology Foundation