Author + information
- Masami Kosuge,
- Toshiaki Ebina,
- Kiyoshi Hibi,
- Kengo Tsukahara,
- Noriaki Iwahashi,
- Nobuhiko Maejima,
- Yoshio Tahara,
- Satoshi Umemura and
- Kazuo Kimura
In patients with acute myocardial infarction (AMI), young obese patients, especially in men, have been recently increasing; however, those clinical features have not been fully elucidated.
We studied 240 men with a first anterior AMI who received fibrinolysis or primary PCI within 6 h after the onset. Patients were divided into the 2 groups: those aged ≤55 years (younger patients, n=102) and those aged >55 years (older patients, n=138). Patients were subdivided into the 2 groups according to the presence or absence of obesity for Japanese defined as baseline body mass index (BMI) ≥25 kg/m2. The degree of myocardial damage before reperfusion therapy was estimated by QRS score on admission ECG. Impaired myocardial reperfusion was defined as myocardial blush grade 0/1 on the final angiogram.
Time to admission, the rate of primary PCI, culprit lesion, initial and final TIMI flow grade, and reperfusion time did not differ in the 4 groups. Young obese patients had higher incidences of hyperlipidemia, smoking, familiar history, and multiple coronary risk factors. Moreover, myocardial damage was more severe, infarct size was larger, and impaired myocardial damage was more frequent in young obese patients.
In patients with a first anterior AMI treated with reperfusion therapy, young obese men are characterized by multiple coronary risk factors, a larger infarct size, and impaired myocardial reperfusion, suggesting the significance of primary prevention for AMI.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Body Size and MI Risk: Is Bigger Better?
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1128M-199
- 2013 American College of Cardiology Foundation