Author + information
- Tatsunori Taniguchi,
- Tomohito Ohtani,
- Yasuharu Takeda,
- Isamu Mizote,
- Yoshihiro Asano,
- Machiko Matsui Kanzaki,
- Yasuhiro Ichibori,
- Yasushi Sakata and
- Issei Komuro
Liver stiffness (LS) in patients with congestive heart failure (HF) may be influenced by right-sided filling pressure, a strong prognostic value in HF. Transient elastography (Fibroscan®) measurements offer a non-invasive approach for LS measurement.
We studied the relationship between right atrial pressure (RAP) measured using a pulmonary artery catheter (PAC) and LS derived by a Fibroscan® device in 62 HF patients. LS measurements were performed in a supine position within 3 hours prior to PAC. Echocardiographic estimation of RAP, based on inferior vena cava (IVC) diameter and collapsibility, was simultaneously performed in a blind manner. We excluded patients with severe obesity, ascites, and chronic liver disease.
The median values for LS and RAP were 8.6 kPa (range 2.8-75.0 kPa) and 9 mmHg (range 1-32 mmHg), respectively, and there was a highly significant correlation between them (r=0.94, p<0.0001). Receiver operating characteristic (ROC) curve analysis illustrated that the area under the curve (AUC) for LS measurements for predicting elevated RAP (>8 mmHg) was larger than that for echocardiographic RAP estimation (p=0.008), with sensitivity and specificity for LS at 87% and 96%, respectively. Intra- and interobserver analyses showed excellent agreement, with intraclass correlation coefficients of 0.997 and 0.997, respectively.
LS measurement by transient elastography may be a novel non-invasive approach to estimate RAP in patients with HF.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: New Diagnostic and Imaging Strategies in Heart Failure
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1136-297
- 2013 American College of Cardiology Foundation