Author + information
- Alexios S. Antonopoulos,
- Charalambos Antoniades,
- Dimitris Tousoulis,
- Michalis Demosthenous,
- Antigoni Miliou,
- Nikolaos Koumallos,
- Costas Triantafyllou,
- Constantinos Bakogiannis,
- Constantinos Psarros and
- Christodoulos Stefanadis
Monocyte chemoattractant protein-1 (MCP-1) is a cytokine with a key role in immune cell chemotaxis and may regulate the cellular infiltration of the myocardium post CABG, while interleukin 6 (IL-6) and hsC-reactive protein (hsCRP) are key regulators of immune response. We examined the predictive role of preoperative MCP-1, IL-6 and hsCRP levels on the development of acute heart failure and the need for inotropic support after CABG.
We recruited 245 patients undergoing elective CABG. The morning before the operation, after 8h of fasting, blood samples were obtained and the levels of MCP-1, IL-6 and CRP were determined by ELISA. The patients were followed-up until their discharge from the hospital. The use of inotropes was recorded during their stay in the hospital.
Patients that required inotropic support post-operatively had significantly higher preoperative levels of MCP-1 (A), IL-6 (B) and hsCRP (C). In multiple regression analysis, MCP-1 and IL-6 were predictors of the use of inotropes in the post-operative period (P<0.05 for both), independently of risk profile and preoperative LVEF.
Preoperative levels of MCP-1, IL-6 and hsCRP are independent predictors of the need of post-operative inotropic support independently of pre-operative left ventricular systolic function in patients undergoing CABG. Our findings identify these biomarkers as potential therapeutic targets for the prevention of post-operative complications after cardiac surgery.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Lessons Learned from Acute Decompensated Heart Failure
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1175-281
- 2013 American College of Cardiology Foundation