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Early statin loading before coronary angiography has shown to reduce ischemic complications in patients undergoing PCI in the course of ACS, and to improve indices of reperfusion in STEMI patients undergoing primary PCI (PPCI) in small prospective randomized studies. The purpose of this study was to evaluate the “real world” effect of statin loading prior to PPCI in a large group of unselected patients undergoing PPCI for STEMI
ACSIS is a 2-month biannual nationwide ACS survey which documents all ACS patients admitted to each of the 26 cardiac departments in Israel. ACSIS 2010 comprised 1781 ACS patients. The study cohort consisted of the 506 patients undergoing PPCI for STEMI
Statin loading was administered before PPCI to 137 patients (27%) and 369 patients (73%) did not receive a statin before PPCI. Both groups had similar baseline characteristics. No difference was found regarding the MI location, the infarct related artery, the number of coronary vessel diseased or the TIMI flow. Although satins were almost universally prescribed at discharge (97% vs. 95%, p=0.34), early statin loading was associated with more frequent early ST- segment resolution (STR) > 70% (81% vs. 67, p= 0.005). Statin loading prior to PPCI remained independent predictor of early STR (Odds Ratio 2.97, CI 1.62-5.45, p=0.00005) in multivariable analysis (Fig)
In patients undergoing PPCI for STEMI, statin loading before PCI is an independent predictor of better myocardial reperfusion.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: ACS Therapy: Key Observational Data
Abstract Category: 3. Acute Coronary Syndromes: Therapy
Presentation Number: 1168-187
- 2013 American College of Cardiology Foundation