Author + information
- Evan Brittain,
- James Muldowney,
- Carrie Geisberg,
- Anthony Caggiano,
- Andrew Eisen,
- Sarah Anderson,
- Douglas Sawyer,
- Lisa Mendes and
- Daniel Lenihan
Glial Growth Factor 2 (GGF2) is a neuregulin peptide critical for myocardial function. GGF2 improves left ventricular function (LVF) in animal models of cardiac injury. We report echocardiographic findings in a first-in-man, double-blind, placebo controlled, escalating single dose study of tolerability of GGF2 in patients with systolic HF.
Patients with LV ejection fraction (EF) <40% and symptomatic HF (NYHA Class II-III) received a single IV dose of GGF2 (0.007[[Unable to Display Character: –]]1.5 mg/kg) or placebo (4:2) in 7 cohorts. Echocardiography was performed at baseline, days 8, 14, 28 and 90.
40 patients (mean age 57 years, 82% male) were enrolled. EF at screening in the placebo and treatment groups was 29±3 and 27±1%, respectively. The change in EF (mean±SD) at D8, D14, and D28 was [[Unable to Display Character: –]]0.8±6.5, −1.1±7.8 and −0.3±8.5% for the placebo group compared to 2.3±8, 11.6±10 and 12±5.1% for the cohort receiving the maximally tolerated dose (0.75 mg/kg). Figure 1.
Single dose GGF2 in patients with symptomatic HF showed a trend towards improving LVF over 28 days compared to placebo. Further studies will determine safety and possible therapeutic effect of repeat dosing of GGF2 on LVF and other cardiac outcomes.
Figure 1. Mean Change In Ejection Fraction Following Single Duse of GGF2 (mg/kg} Or Placebo
Oral Contributions South, Room 104
Sunday, March 10, 2013, 11:45 a.m.-Noon
Session Title: Joint Session of the Heart Failure Society of America and American College of Cardiology
Abstract Category: 17. Heart Failure: Therapy
Presentation Number: 925-7
- 2013 American College of Cardiology Foundation