Author + information
- Megan H. MacNabb,
- Amr Abdelbaky,
- Zachary R. Lavender,
- Rebecca S. Kaplan,
- Marcelo di Carli,
- Viviany Taqueti,
- Courtney Foster,
- Jessica Mann,
- Robert Comley,
- Chek Ing Kiu Weber and
- Ahmed Tawakol
To assess arterial inflammation, using 18-F-fluorodeoxyglucose positron emission tomography/computed tomography imaging (FDG-PET/CT), in patients with chronic kidney disease (CKD).
Patients (N=322, mean age±SEM: 68.7±0.5, 58% male) undergoing FDG-PET/CT imaging for clinical indications were studied retrospectively: 166 patients with CKD and 166 control patients without CKD (matched by age, gender, and presence/absence of clinical atherosclerosis). CKD was defined per NKF guidelines with a calculated glomerular filtration rate (GFR). Arterial inflammation was assessed by measuring aortic FDG uptake by PET, while blinded to patient identifiers.
Arterial inflammation was higher in patients with CKD compared to matched controls (standardized uptake value, SUV: (2.34 ±0.04 vs. 2.15 ±0.04; p<0.001). Group differences remained significant after correcting for background SUV (target to background ratio). SUV was also elevated in CKD among patients with FRS<10 (p<0.001). Arterial SUV correlated inversely with GFR after adjusting for cardiovascular risk factors, cancer and statin use (R=-0.2, p<0.001).
CKD is associated with increased arterial inflammation beyond that of controls. Current risk stratification tools may underestimate presence of atherosclerosis in patients with CKD. Further studies are required to evaluate whether attenuation of the arterial inflammatory process will decrease cardiovascular events in CKD.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Cardiac PET: Towards Flow Quantification and Novel Applications
Abstract Category: 21. Imaging: Nuclear
Presentation Number: 1139-329
- 2013 American College of Cardiology Foundation