Author + information
- Satoshi Tsujimoto,
- Yoko Miyasaka,
- Yoshinobu Suwa,
- Hirofumi Maeba,
- Kazuhiro Yamamoto and
- Ichiro Shiojima
Lower diastolic wall strain (DWS) is recently reported as a simple echocardiographic predictor of heart failure (HF) hospitalization or death in patients with HF and preserved EF. We sought to evaluate whether DWS predicts cardiovascular events in patients without clinical HF.
Among patients referred for clinically-indicated echocardiogram, those with EF>=50% and no clinical HF or cardiac structural abnormalities were consecutively included. Cardiovascular events were ascertained using Framingham criteria (myocardial infarction, coronary insufficiency, stroke, transient ischemic attack, congestive HF, or cardiovascular death). DWS was calculated with a validated formula. Cox proportional hazards modeling was used to assess risk of cardiovascular events.
Of a total number of 975 patients (61 ± 15 year-old, 48% men, 50% hypertension, 18% diabetes), 33 (3.4%) developed cardiovascular events during a mean follow-up of 19.4 ± 14.0 months. Cardiovascular events were significantly increased with advancing age (HR 1.6, 95%CI 1.2-2.3) and male sex (HR 2.8, 95%CI 1.3-6.0). After adjusting for cardiovascular comorbidities in a multivariate model, low-DWS (=<0.33) was a significant predictor of cardiovascular events (HR 2.5, 95% Cl 1.1-5.6). The Kaplan-Meier estimates of events-free survival by DWS status were shown (Fig).
Echocardiographic assessment of DWS may help identifying the population of patients at high risk for future cardiovascular events.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: LV Diastolic Function
Abstract Category: 18. Imaging: Echo
Presentation Number: 1143-362
- 2013 American College of Cardiology Foundation