Author + information
- Maria I. Drakopoulou,
- Konstantinos Toutouzas,
- Constantina Aggeli,
- Konstantina Masoura,
- Felekos Ioannis,
- Charalampia Nikolaou,
- Andreas Synetos,
- Charalampos Grassos,
- Elias Siores,
- Eleftherios Tsiamis and
- Christodoulos I Stefanadis
Both plaque angiogenesis and inflammation contribute in the development and progression of atherosclerosis. Contrast-enhanced ultrasound (CEUS) provides direct visualization of the adventitial vasa vasorum. Microwave radiometry (MR) allows in vivo measuring of internal temperature of tissues. We sought to investigate in vivo non-invasively in human carotid arteries whether plaque neovascularization and plaque temperature are associated with ultrasound findings.
Consecutive patients with coronary artery disease and carotid atherosclerosis underwent carotid ultrasound imaging, CEUS and MR. Plaque texture, plaque surface and plaque echogenicity were analyzed. Contrast enhancement (CE) by CEUS was defined as the % percentage of signal intensity difference, prior and post contrast infusion. Thermal heterogeneity (?T) was assigned as maximal temperature along the carotid artery minus minimum.
Eighty-six carotid arteries of 48 patients were included. Fatty plaques had higher CE% and ?T compared with mixed and calcified (p<0.01). Heterogeneous plaques had higher CE% and ?T compared with homogenous (p<0.01). Plaques with irregular surface had higher CE% and ?T compared with plaques with regular (p<0.01) (Table).
Carotid plaque neovascularization on CEUS examination is associated with increased thermal heterogeneity by MR and ultrasound characteristics of plaque vulnerability in intermediate lesions.
|Ultrasound Characteristics||Number of carotid plaques=86||CE%||P values for CE%||ΔT(°C)||P values for ΔT(°C)|
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: Echo – Contrast Echocardiography/Vascular Imaging
Abstract Category: 18. Imaging: Echo
Presentation Number: 1225-331
- 2013 American College of Cardiology Foundation