Author + information
- Ahmet Çelik1,
- Mehtap Gürger2,
- Çağdaş Can3,
- Mehmet Balin2,
- Evrim Gül3,
- Mehmet Ali Kobat3,
- Umut Gümüşay3,
- Mustafa Şahan3,
- Kazım Burak Bursalı3,
- İlyas Celiker3,
- Suna Aydın3 and
- Süleyman Aydın2
Nesfatin-1 was originally identified as a neuropeptide of the hypothalamus, which is a key integration area of the brain, where numerous neuropeptides and transmitters are released to participate in the control of essential body functions. In the literature, there are no studies showing the relationship between the nesfatin-1 level and paroxysmal supraventricular tachycardia. We hypothesize that the circulating levels of nesfatin-1 may increase during supraventricular tachycardia, to engage the vagal stimulation to terminate by the inhibition of neuropeptide-Y, andmay activate oxytocin and the corticotropin-releasing hormone.
This study includes 120 cases (80 patients and 40 controls). Patients with paroxysmal supraventricular tachycardia were compared with the control group with regard to sex, nesfatin-1 level, comorbid diseases, serum renal function values, and patients’ vital findings.
The baseline characteristrics of study subjects were summarized in Table 1. Figure 1 shows the difference of nesfatin-1 levels in two groups. nesfatin-1 levels were positively correlated highly with heart rate (r=0.634; P G 0.001). Figure 2 shows the ROC analysis of nesfatin-1 levels. The area under the receiver operating characteristic curve was 0.644 for the nesfatin-1 levels (P=0.0051). The sensitivity and specificity values of the nesfatin-1 levels were 41.2% and 95%, respectively (cutoff value 91743.7 pg/mL).
At the end of this study, a statistically significant correlation was found between the serum nesfatin-1 level and supraventricular tachycardia. Although multifactorial causes may explain the relationship, we based our hypothesis on the relationship of the antagonistic effects of nesfatin-1 on the neuropeptide-Yand activated oxytocin.
|PSVT Group (n=80)||Control Group (n=40)||P value|
|History of (%)|
|Systolic BP (mmHg)||130± 19||123± 14||0.05|
|Diastolic BP (mmHg)||77±8||75±7||0.09|
|Heart rate (beat/min)||169±20||82±13||<0.001|
The characteristic properties of study patients