Author + information
- Berkay Ekici1,
- Ramazan Oğuz Şahin2,
- Meltem Altınsoy1,
- Savaş Açıkgöz4,
- Rabia Şeker3,
- Selda Demirtaş3 and
- Fatma Şule Korkmaz1
S100, a calgranulin family protein released from white blood cells, is involved in inflammatory cardiovascular disease. It was hypothesized that the plasma level of S100 can be used to predict outcome in patients with chronic coronary artery disease (CAD). We aimed to determine the relationship between S100 protein levels and angiographic SYNTAX score, which gives information about the severity and complexity of CAD in patients with acute coronary syndromes.
This pilot study included 77 patients who were admitted to the emergency room for the evaluation of the angina pectoris. According to the clinical status and cardiac enzyme levels the patients had undergone coronary angiography. The serum S100 protein levels were measured at the administration. The independent association between serum S100 protein and the severity of CAD was statistically evaluated using PASW Statistics 18 for Windows.
Mean age of the study population was 61.27±13.50 years, of whom 39 were female (50.6%) and 38 male (49.4%). Of the patients, 23.4% had diabetes mellitus, 63.6% had hypertension, 44.2% had hyperlipidemia, and 39.0% were smokers. Mean SYNTAX score was 12.5±12.2. According to SYNTAX scores, 59 of the patients (76.6%) had no significant CAD or normal coronary arteries (SYNTAX score:0-22), 18 of the patients (23.4%) had moderate to severe CAD (SYNTAX score ≥23). Mean serum S100 protein values were 0.37±0.90 μg/l in the group that had normal coronary arteries, 0.20 ± 0.46 μg/l in the group with NSTEMI, and 0.11±0.12 μg/l in the group with STEMI. According to Spearman analysis, no correlation was found between serum S100 protein and SYNTAX score (p=0.284, r=0.124). Also, there was no statistically significant correlation between s100 and troponin-t levels (p=0.051, r=0.256).
Previously, it was reported that, rising levels of serum S100 protein was a specific and sensitive clinically relevant marker of acute coronary syndromes. Contrary to the literature, we did not determine any correlation between S100 protein levels and SYNTAX score. It can be explained by the small-scale of the study. Larger-scale studies should be performed to shed light on this topic.