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Our purpose was to investigate the relationship between the prevalence of glucose intolerance and type 2 diabetes with cardiometabolic risk factors in patients with asymptomatic coronary artery disease.
132 patients who had not been previously diagnosed with glucose intolerance or diabetes, and had coronary artery disease (CAD) were enrolled. 2 hour standard oral glucose tolerance test (OGTT) with 75 gr. glucose was conducted. Patients were divided into two groups as normal and with impaired glucose tolerance (IGT) or diabetes (DM). Groups were compared according to waist circumference, body-muscle index, creatinin clearance, risk factors of CAD, severity of CAD, functional capacity, angina score. In patients with Fasting plasma glucose (FPG) <100 mg/dl, HOMA-IR values were investigated. For statistical analysis, t-test, Mann-Whitney U, Kruskal Wallis or logistic regression test were used.
Prevelance of IGT(%26) or DM (%4) was %30 in patients with CAD. %27 of patients had a value of FPG <100 mg/dl before the test was conducted. Between the groups, waist-hip ratio, creatinine levels were significantly high; glomerular filtration rate (GFR) was low in IGT or DM group compared to the other one whose OGTT test was normal. In these parameters, GFR predicted IGT or DM with %72 sensitivity and %55 specifity. Before the test, patients with FPG <100 mg/dl, %30 of patients had insülin resistance.
In significant part of patients with CAD, IGT or DM was present despite normal FPG. Conventional risk factors, severity or duration of CAD cannot predict IGT or DM. OGTT testing for IGT or DM, independent from FPG, would contribute to the diagnosis.