Author + information
- Burçak Kılıçkıran Avcı,
- Barış İkitimur,
- Özge Özden Tok,
- Murat Cimci,
- Emre Ertürk,
- İlkin Babayev,
- Timur Bigmourad,
- Bilgehan Karadağ,
- Vural Ali Vural and
- Zeki Öngen
The Global Registry for Acute Coronary Events (GRACE) and the Thrombolysis in Myocardial Infarction (TIMI) risk scores predict adverse clinical outcomes in patients with non-ST elevation acute coronary syndromes (NSTEACS). In the present study, we sought to determine whether GRACE and TIMI risk scores correlate with angiographic extent and complexity of coronary artery disease (CAD) according to SYNTAX score (SXscore) in patients with NSTEACS undergoing catheterization.
We performed a retrospective analysis of 167 consecutive NSTEACS patients (mean age: 59±11 years) who underwent coronary angiography and had at least one significant vessel disease (>50% stenosis in a vessel ≥1.5 mm). SXscore, a marker of CAD severity, was assessed from angiograms using the SXscore algorithm as described in detail on the SXscore web site. In order to investigate predictive ability of clinical risk scores in determination of CAD severity, patients were divided into 3 groups according to their GRACE risk scores: GRACE scores 0 to 108 (low, n=68), 109 to 140 (intermediate, n=51), and >140 (high, n=48). Similarly, patients were classified into 3 categories according to TIMI risk scores: TIMI scores 0 to 2 (low, n=51), 3 to 4 (intermediate, n=94), and 5 to 7 (high, n=21).
The SXscore ranged from 2 to 76 with a mean value of 17.5±14.0. There were significant correlations between SXscore and GRACE (r=0.260, p=0.001) and TIMI (r=0.222, p=0.004) risk scores. There was a significant trend for higher SXscore in higher GRACE and TIMI score groups (Table 1 and 2).
In patients with NSTEACS, both GRACE and TIMI risk scores are correlated with the extent and severity of CAD. Therefore, in patients with higher GRACE and TIMI risk scores, CAD can be predicted to be more diffuse and severe.
|Low (0-108)||Intermediate (109-140)||High (>140)||P value|
|SYNTAX score||12.9 ± 10.0||20.1 ± 16.5||21.2 ± 14.5||0.002|
|Low (0 - 2)||Intermediate (3 - 4)||High (5 - 7)||P value|
|SYNTAX score||13.7 ± 10.9||17.5 ± 13.3||27.2 ± 19.4||0.001|