Author + information
- Filiz Geyik1,
- Neslihan Çoban1,
- Berna Yüzbaşıoğulları1,
- Altan Onat2,
- Vedat Sansoy3,
- Can Günay4 and
- Nihan Erginel Ünaltuna1
Obesity, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. The risk of obesity is determined not only by specific genotypes but also by significant gene-gene interactions. Several studies have established associations of both apolipoprotein A4 (APOA4) gene variants and fat mass and an obesity associated (FTO) gene variants with blood lipid levels and obesity. Our aim was to explore the synergistic contribution of the two polymorphisms: T347S of the APOA4 gene and rs1421085 of the FTO gene to obesity risk in a Turkish adult population.
We investigated a possible interaction between these two genes on the risk for the obesity, using data from the TARF study (1512 men and women aged 50.06±12.01 years). Genotyping was achieved by high throughput systems as Real-Time PCR LC480 and ABI-7900HT. Statistical analysis was performed by conditional multiple regression models.
APOA4 T347S and FTO rs1421085 polymorphism combinations showed a nominal gene-gene interaction (p values 0.014 and 0.030 respectively) on obesity. Logistic regression analyses of T347S ve rs1421085 polymorphisms, after adjustment for age and gender these interactions were also showed (p for interaction =0.007 and =0.027, respectively).
A synergistic effect between polymorphism T347S of the APOA4 gene and rs1421085 of the FTO gene for obesity risk was found in Turkish adult population.