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It has been revealed that many factors can take a part in pathogenesis of primary hypertension. One of these factors is abnormal angiogenesis. In this study we aimed to investigate the levels of VEGF, an angiogenic factor, and Tie-2, angiopoetin receptor, in individuals with hypertension and some biochemical parameters related to the hypertension.
In the present study 90 individuals have been divided in to 3 groups as 30 patients with primer hypertension (Patient group), 30 healthy individuals with normal blood pressure but with positive family story (Control group 2) and 30 healthy individuals with normal blood pressure and negative family story(Control group 1). All individuals have been evaluated in terms of blood pressure and biochemical parameters. The levels of VEGF and Tie-2 have been evaluated by using ELISA method.
In patient group, while Tie-2, VEGF, LDL and triglycerides levels have been found high, the levels of HDL has been found low (p<0,05 Table 1 Figure 1, Figure 2). In correlation analysis, while positive correlation has been found in between hypertension levels and Tie-2 receptor levels (p<0,05 Figure 3), there was no significant correlation in between hypertension levels and VEGF levels (p>0,05).
As a result of this study, these results indicate that VEGF and Tie-2 receptor may be related to the primer hypertension.
|Patient||Control 1||Control 2||p|
|HDL (mg/dl)||37,80±8,93||43,03±7,58||33,93±4,38||0,001 *|
|LDL (mg/dl)||93,37±27,30||69,80±14,72||71,30±10,94||0,001 *|
|TG (mg/dl)||139,20±80,30||83,06±16,32||79,26±18,96||0,001 *|
HDL,high-density lipoprotein;LDL,Low-density lipoprotein;TG,triglycerides. * The difference between with the control group 1 and patients.The difference between with control group 2 and patients is insignificant ((p>0.05)