Author + information
- Shigeki Kobayashi,
- Takeki Myoren,
- Wakako Murakami,
- Masakazu Fukuda,
- Shinichi Okuda,
- Tomoko Nao,
- Jutaro Yamada,
- Takayuki Okamura and
- Masafumi Yano
We investigated whether urinary (U) 8-hydroxy-2¢-deoxyguanosine (8-OHdG), an oxidative DNA damage marker, was related to inflammatory activity in cardiac sarcoidosis(CS).
U-8-OHdG levels were measured in 31 CS patients, classified as active (n = 17) or non-active (n = 14) based on 18F-FDG-PET/CT. In active CS patients, U-8-OHdG levels were re-examined and compared with 18F-FDG-PET/CT results at 6 months after corticosteroid treatment to assess therapeutic response.
Immunohistochemical examination of left ventricle (LV) autopsy samples from CS patients revealed positive 8-OHdG staining in cardiomyocyte nuclei from LV sections showing 18F-FDG accumulation on PET/CT, while serum 8-OHdG levels were significantly higher in the coronary sinus than in the aortic root only in active CS patients. U-8-OHdG levels in CS patients were higher than those in controls, and significantly higher in active CS patients than in non-active CS patients. U-8-OHdG was a powerful predictor of active CS in ROC curve analysis (AUC, 0.98; optimal cutoff value, 13.1 ng/mg creatinine; sensitivity, 88.2%; specificity, 92.9%). U-8-OHdG level in patients with active CS was significantly decreased 6 months after corticosteroid treatment, in proportion with a decrease in the focal pathological tracer uptake in heart.
U-8-OHdG is a potentially clinically useful biomarker for evaluating inflammatory activity and monitoring the effectiveness of corticosteroid therapy in CS patients.
Saturday, March 29, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Heart Failure and Cardiomyopathies: Diagnostic, Prognostic and Therapeutic Strategies in Cardiomyopathies
Abstract Category: 12. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1147-172
- 2014 American College of Cardiology Foundation