Author + information
- Ioannis Felekos,
- Constantina Aggeli,
- Athanasios Angelis,
- Konstantinos Toutouzas and
- Dimitris Tousoulis
Study purpose was to evaluate the prognostic value of Dobutamine stress contrast echo (DSCE) in diabetics with known or suspected CAD, according to appropriateness indication.
We studied 2380 patients.Patients were classified as diabetics and non-diabetics and were stratified according to appropriateness criteria as appropriate (A), uncertain (U) and inappropriate (I). Follow-up lasted 57.1 ± 10.1 months. End points included all-cause mortality, cardiac death, the need for late revascularization (>3 months) and hospitalizations.
Of 2380 patients (58.8 ± 9.9 years), 45.6% were classified as appropriate, 31.7% as inappropriate and 22.7% as uncertain. DSCE was positive in 27.2% of diabetic patients, and in 18.5% of non-diabetics.There was significant difference among the two groups regarding MACE (14% vs. 8.6%, p<0.05). Multivariate analysis showed that DSCE response was the strongest predictor for MACE (x2 = 51.7, p<0.05) in both groups. The model including DSCE results along with clinical data performed significantly better than the clinical model alone (C-index 0.937 vs 0.7 for non-diabetics and 0.875 vs 0.680 for diabetics, p<0.0001 in both cases). Diabetics had more events than non-diabetics in the Appropriate class (x2 = 8.53, p<0.05).However, there was no significant difference in outcomes between the two groups in the Inappropriate class (x2 = 3.55, p=NS).
Patients with Inappropriate indication fare well, regardless diabetic status.
Poster Area, South Hall A1
Sunday, April 03, 2016, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Applications of Echocardiography: Part II
Abstract Category: 29. Non Invasive Imaging: Echo
Presentation Number: 1231-252
- 2016 American College of Cardiology Foundation