Author + information
- Heidi Thomas May,
- Kimberly Brunisholz,
- Benjamin Horne,
- J. Muhlestein,
- Tami Bair,
- Donald Lappe,
- Adam B. Wilcox and
- Brenda Reiss-Brennan
Depression is known to be a risk factor for adverse cardiovascular (CV) outcomes. However, how changes in depressive symptom severity affect CV risk is not clear.
Pts (N=7550) who completed two patient health questionnaire (PHQ)-9 surveys >90 days apart and were >40 yrs of age were studied. Pts were stratified into 4 groups: no depression (first and last PHQ-9 score <9, n=3286), no longer depressed (first PHQ-9 >10 with improvement [reduction] in score of >5 and last PHQ-9 score <9, n=1542), remained depressed (first and last PHQ-9 >10, n=1987), and became depressed (first PHQ-9 <9 with an increase score >5 and last PHQ-9 >10, n=735). Pts were followed from the last PHQ-9 for MACE (death, CAD diagnosis, MI, stroke, and HF hospitalization).
Pts averaged 57±12 yrs and 70% were female, which differed significantly between groups. History of CAD, stroke, and HF were similar between groups. MACE frequency among those with no depression, no longer depressed, remained depressed, and became depressed were 4.8%, 4.6%, 6.0%, and 6.4%, respectively (p-trend=0.03). After adjustment, those no longer depressed had a similar MACE risk as those never depressed and those with depression (remained and became) were at an increased risk (Figure).
This study has produced observational evidence that not only is depression associated with increased CV risk, but prompt effective treatment may reduce the risk of future MACE. These findings justify confirmation with a randomized clinical trial.
Poster Area, Poster Area, South Hall A1
Saturday, April 2, 2016, 3:45 p.m.-4:30 p.m.
Session Title: Role of Biomarkers and Therapeutic Lifestyle in Preventive Cardiology
Abstract Category: 33. Prevention: Clinical
Presentation Number: 1156-381
- 2016 American College of Cardiology Foundation