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The prognosis of Premature Ventricular Contraction (PVC) in general population is on controversy. The PVC in general population used to be considered as benign. However, recently some research prompts it may be harmful to live and cardiac function. The relation between PVC in general population and all-cause mortality in China is not known, which is important for the improvement of life expectancy in China. The purpose of this study is to determine whether PVCs increase the risk of all-cause mortality in general population, calculate the prevalence and incidence of PVCs, and find out the risk factors and the predictors for PVCs in a general population-based cohort.
We studied 99594 people, who participated in the physical examination containing the ECG diagnose, without the diagnoses of Wolff Parkinson White syndrome, atrial fibrillation or atrial flutter in the first examination. All the anthropometric and biochemical measurements came from the first examination. Participates were followed for the all-cause mortality and incident of PVCs.
The 1000 person-year mortality of people without PVCs is 7.72 and that of people with PVCs is 20.60. And according to the Cox regression, PVCs increase the risk of all-cause mortality for more than 30%.
The prevalence is 1.1% in the whole people. The prevalence of PVCs increases with the age ascending in the middle age and old people especially after 65 years old. And in both male and female prevalence increases with age ascending, but the trend for men is more abrupt than that for women. In addition, we also find that before 55 years old the prevalence for female is comparable with or even higher than that for male, but after 55 years old the prevalence is higher for men previously.
The six years' follow-up detected 1275 people who were newly affected with PVCs in the 86700 subjects (didn't have PVCs in 2006). The one thousand person year incidence in the whole group is 2.69 (2.84 for male, 2.16 for female). The risk factors for the incident of PVC are age, hypertension, FBG (fasting blood glucose), hyperuricemia and the predictors are age, gender (male), hypertension, FBG (fasting blood glucose).
In a general population based sample, PVC (checked out by 12 lead electrocardiograms) means a higher risk of all-cause mortality. The prevalence and incidence of PVCs increase with the age ascending in the middle age and old people especially after 65 years old. Before 55 years old the prevalence for female is similar with or even higher than male, but after 55 years old the prevalence is higher for male previously. We could prevent PVC by control blood pressure FBG uric acid in a normal range.