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Twenty-four hour ambulatory blood pressure monitoring (ABPM) is an accurate method to document changes in blood pressure and is more predictive than office blood pressure (OBP) and home blood pressure (HBP) monitoring for cardiovascular outcomes in elderly people, but the relationship between ABPM indices and renal damage in elderly Chinese male patients with essential hypertension remains unclear.
we investigated 998 Chinese men (mean age, 78.44±12.02 years). Participants underwent renal function, laboratory testing, and ABPM, including ABP, BP variability, and BP circadian rhythms. The relationships between ABPM indices and renal damage (expressed by urine protein, urine albumin: creatinine ratio [uACR], estimated glomerular filtration rate [eGFR], blood urea nitrogen [BUN], and serum uric acid [sUA] levels) were assessed using ridge regression analysis.
After adjustments for age, common cardiovascular diseases and medications, the uACR level was positively associated with 24h mean systolic blood pressure (24hmSBP), daytime SBP (dSBP), 24h mean pulse pressure (24hmPP), day mean pulse pressure (dmPP), nocturnal mean pulse pressure, and 24h SBP percent time of elevation (24hSBP PTE%). The eGFR level was negatively associated with the 24hmPP and dmPP, and the BUN level was positively correlated with the 24hmSBP, 24hmPP, and 24hSBP PTE%, whereas the BUN level was negatively associated with the 24h DBP standard deviation.
Our study indicated that the ABPM indices associated with renal damage may be regarded as an early predictive marker for renal function impairment in elderly male patients with hypertension.