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To observe the effects of Xinmailong injection on the cardiac function and extravascular lung water in patients with acute heart failure.
43 AHF patients were randomly divided into the Xinmailong treatment group(n=20) and the control group(n=23). The two groups were both given routine treatment of anti-heart failure. But the treatment group was given additional intravenous drip of Xinmailong injection (5mg/Kg) and 100ml 0.9% sodium chloride solution two times daily for 5 consecutive days. The levels of LVEF and plasma BNP were detected in the two groups before and after treatment. The B-pattern obtained by lung sonography was detected to assess the extravascular lung water.
After treatment, the LVEF was higher (51.30±2.88 VS 47.26±2.62), while the plasma BNP (1329.90±295.82 VS 2024.81±496.33) and B-pattern(33.43±6.28 VS 42.52±6.19) were lower in the control group. Moreover, in the Xinmailong treatment group, there were significant improvement in the LVEF(60.10±2.56 VS 48.55±2.68), plasma BNP (719.68±94.15 VS 1564.41±218.85) and B-pattern (23.70±4.86 VS 64.70±9.76) compared with before treatment. Furthermore, the improved degree of LVEF, plasma BNP and B-pattern in the Xinmailong treatment group were higher than the control group after treatment (P < 0.05).
Xinmailong injection improves cardiac function and reduces the extravascular lung water in patients with acute heart failure.