Author + information
- Umida Kabirovna Kamilova,
- Zulfya Rasulova and
- Dilafruz Masharipova
To study dynamics of the levels of brain natriuretic peptide Nt-proBNP, aldosteron (AL) and noradenalin (NA) in the blood serum of the patients with chronic heart failure (CHF) in dependence on use of β-blockers, angiotensin II receptor antagonists (ARA) or angiotensin-converting enzyme inhibitors (iACE).
There were studied 46 patients with CHF with FC II (24 patients) and FC III (22 patients). The patients received bisoprolol (5-10 mg) and lisinopril (10-20 mg) or lozartan (50-100 mg) additionally to the standard therapy during 6 months.
In the patients with CHF FC II there was increase in contents of BNP, NA and AL by 187%, 30% and 36% (p<0,001), in patients FC III by 330%, 56% and 66,3% (p<0,001), respectively, in comparison with control group.
There was no reliable change in increase in activity of two and more neurohormones (BNP, AL, and NA) in the patients with increased contents of NA or two and more studied neurohormones of the ejection fraction from left ventricle (LV EF) to the 6 month. In the patients with unreliable increase in neurohormones or increase only one of above mentioned neurohormones there was noted reliable (p<0,05) increase in LV EF 6 months after treatment.
Combined therapy with β-blockers and iACE or ARA allowed achievement absence of increase in activity of studied neurohormones and reliable lower content of NA 6 months after treatment. There were no reliable differences in groups of patients receiving losartan or lizinopril on the dynamics of the neurohormones levels.