Author + information
- Jia Xu,
- Ye Zhang,
- Jinli Liao,
- Yan Xiong,
- Ziyu Zheng and
- Hong Zhan
Circulating endothelial progenitor cells are specialized subset of stem/progenitor cells derived from bone marrow. The number and activity of EPCs influenced its ability of neo-vascularization of injured vessels and predict the outcome in patients with aortic dissection. We aimed to evaluate the distinct patterns of circulating endothelial progenitor cells in aortic dissection.
We studied 26 consecutive patients with initial diagnostic aortic dissection and17 healthy subjects as control group. In all patients, the number of circulating EPCs of peripheral vein were measured by flow cytometer. Levels of soluble vascular endothelial growth factor (VEGF) and soluble vascular cell adhension molecule (sVCAM) were detected by ELISA. Stromal derived factor-1α (SDF-1α) of plasma and culture medium level ofcirculating EPCs were measured by ELISA.
Compared to controls, CD34+/CD133+ EPCs numbers were much higher in aortic dissection group with significantly elevated plasma levels of VEGF and sVCAM. Both plasma and cultured supernatant SDF-1α levels of circulating EPCs were significantly higher in aortic dissection patients compared to healthy volunteers group.
Our findings indicated that number and activity of circulating EPCs levels could be up-regulated when aortic dissection occurred with a plasma biomarker SDF-1α elevated.