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To analyse the metabolic pathways of myocardial infarction(MI) model of of rats by bioinformatics method.
The research literature of MI of rats were retrieved from China Knowledge Resource Integrated Database (CNKI), Wanfang Data Resource System (WANFANG DATA), VIP network (VIP), PubMed and Embase. The metabolic products described in the literature were collected and summarized. Molecular function annotation used HMDB database;Signaling pathways were analysised using KEGG database;Andmetabolites pathway visualization was performed with Metabolomics Pathway Analysis(MetPA).
A total of 26 metabolic product were identified identified more than 2 times in the included literatures.Those metabolites related to 29 metabolic pathways.By using topology analysis, a total of 5 metabolic pathways that were selected and regarded as the metabolic pathways of MI in rats.They were Aminoacyl-tRNA biosynthesis; Glycine,serine and threonine metabolism; Valine, leucine and isoleucine biosynthesis; Biosynthesis of unsaturated fatty acids; Phenylalanine,tyrosine and tryptophan biosynthesis.
The bioinformatics analysis of metabolites of MI in rats showed that the nosogenesis of MI related to the metabolism and metabolic pathways of carbohydrates metabolism, proteinmetabolism,fatmetabolism and RNA transport.The results of this study may have some implications for finding new diadynamic criterias and methods of MI.