Author + information
- Zhenguang Li,
- Hairong Sun,
- Duanlan Ma,
- Pengfei Wang,
- Jiangshan Zhang,
- Zhancai Yu and
- Jinbiao Zhang
To investigate the relationship between pre-operative plasma lipoprotein-associated phospholipase A2 (LP-PLA2) levels and recurrence of atrial fibrillation (AF) in patients after catheter ablation.
A total of 85 consecutive AF patients were studied, 54 of them with paroxysmal AF and 31 with persistent AF, all patients received catheter ablation. The patients were followed-up for 1 year, and then, divided as Recurrence group and Non-recurrence group. The pre-operative plasma LP-PLA2 level, echocardiography and other clinical examinations were conducted in all patients.
During 12 months follow-up period, the total AF recurrence rate was 28.2% (24/85) including 22.2% (12/54) of paroxysmal AF and 38.7% (12/31) of persistent AF. LP-PLA2 level in Recurrence group was higher than that in Non-recurrence group, (195.8±13.1) ng/ml vs (171.6±10.5) ng/ml, P<0.05. In paroxysmal AF patients, LP-PLA2 level in AF recurrence patients was higher than that in non-recurrence patients(P<0.05); and in persistent AF patients, LP-PLA2 level in recurrence patients was higher than that in non-recurrence patients (P<0.05). Multivariate Logistic regression analysis presented that increased LP-PLA2 level was significantly related to AF recurrence, OR=1.18, 95%CI (1.06-1.30), P=0.003.
Pre-operative plasma LP-PLA2 level related to AF recurrence in patients after catheter ablation, and LP-PLA2 may be a useful marker for the predicting AF recurrence after ablation.