Author + information
- In-Jeong Cho,
- Hyuk-Jae Chang,
- Ji Min Sung,
- Hyeon Chang Kim and
- Namsik Chung
Background: Conflicting data exist regarding the association of body weight changes with all-cause and cardiovascular (CV) mortality. The current study investigated the association between weight changes and all-cause, CV, and non-CV mortality in a large cohort of middle-aged adults.
Methods: In total, 379,535 adults over 40 years of age without pre-existing CV diseases or cancer at baseline were enrolled to undergo a series of health examinations at least 3 times. Changes in body mass index (BMI) at baseline, midpoint follow-up, and last health examination were ascertained and stratified into 4 categories as: stable, sustained gain, sustained loss, and weight fluctuation according to weight change patterns. The relationship between BMI weight gain categories and mortality were assessed by multivariate Cox regression reporting hazard ratios (HR) with 95% confidence intervals (95% CI).
Results: During a mean follow-up of 10.7 years, 12,378 deaths occurred from all-causes: of which 2,114 were CV and 10,264 non-CV deaths, respectively. Sustained weight gains lowered the risk of all-cause (HR 0.85, 95% CI: 0.79-0.90), CV (HR 0.82, 95% CI 0.70-0.96) and non-CV mortality (HR 0.85, 95% CI 0.79-0.91) as compared with stable weight gains. Conversely, sustained weight loss displayed a higher (HR 1.07, 95% CI 1.01-1.13) risk of all-cause mortality, which was mainly attributable to the increase in non-CV mortality. According to gender, sustained weight gains among men conferred a lower (HR 0.89, 95% CI 0.82-0.97) risk of non-CV mortality, while sustained weight gains in women mitigated (HR 0.64, 95% CI 0.49-0.85) the risk of CV mortality.
Conclusions: Sustained weight gains were associated with lowering the risk of all-cause, CV, and non-CV mortality in middle-aged adults, with some disparity observed by gender.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-063
- 2017 American College of Cardiology Foundation