Author + information
- Karola Jering,
- Di Zhao,
- Eliseo Guallar,
- Ian de Boer,
- Bryan Kestenbaum,
- Pamela Lutsey,
- Moyses Szklo,
- Darcy Majka and
- Erin Michos
Background: Low 25-hydroxyvitamin D [25(OH)D] and autoimmunity are both associated with increased cardiovascular disease (CVD) risk; yet their joint influence on CVD is unknown.
Methods: We studied 6,281 MESA participants with serum levels of 25(OH)D and autoantibodies [ANA, aCL, anti-β2GPI, RF, CCP (see table for definitions)] measured at baseline (2000-2002) and followed for incident CVD events through 2013. Cross-sectional associations between 25(OH)D and prevalent autoantibodies were assessed using Poisson regression models. Longitudinal associations between prevalent antibodies and incident CVD, stratified by 25(OH)D groups, were determined by Cox Hazard models.
Results: Participants had baseline mean (SD) age of 62 (10) yrs; 53% were women. 25(OH)D deficiency (<20 ng/mL) was present in 33% and autoantibodies measurable in 40% with a higher prevalence in women (p<0.001). There was no cross-sectional association between 25(OH)D status and autoantibodies even after stratification by sex and adjusting for lifestyle factors with the exception of RF IgA where deficient 25(OH)D was associated with positivity [PR 1.24 (95% CI 1.03, 1.50), Table Part A]. Over a median followup of 12.1 yrs, only ANA positivity was associated with increased CVD risk [HR 1.29 (1.01, 1.65), Table Part B], but 25(OH)D status did not modify this association.
Conclusions: Vitamin D status was associated with RF IgA levels but not with other autoantibody markers and did not modify associations between ANA positivity and CVD.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-053
- 2017 American College of Cardiology Foundation