Author + information
- Alyssa Corleya,b,
- Malachy Sullivana,b,
- Scott Friedmana,b,
- Daniel O'Rourkea,b,
- Robert Palaca,b and
- Anthony Gemignania,b
Background: Patients with cancer have increased risk for venous thromboembolism (VTE). However, the risk of arterial thrombosis in patients with types of cancer at high risk for VTE has not been described. The goal of this study is to determine the rate of arterial thrombosis in patients with different types of solid tumors stratified by VTE risk.
Method: Using the 2012 National Inpatient Sample, we identified 373,789 hospitalizations involving patients >18 years associated with solid tumors, stratified by type. Data were collected on clinical characteristics, venous thromboembolism (deep vein thrombosis (DVT) and pulmonary embolism (PE)) and arterial thrombosis (primary diagnosis of myocardial infarction (MI) and ischemic stroke). Subjects with solid tumors (stages I-IV) were stratified by VTE risk, and grouped into high vs. low risk categories. Multivariate logistic regression was performed using comorbidity variables included in the dataset as well as those extracted from diagnostic codes to evaluate the contribution of cancer type to primary outcomes.
Results: Of the 26 solid tumor types evaluated, seven (esophageal, lung, melanoma, ovarian, pancreatic, stomach and uterine) were found to be associated with a higher rate of VTE compared to other cancer types (6.7% vs. 4.0%, p<0.001). Multivariate analysis applied to the high VTE risk group showed no increased risk for MI (OR 0.99, p 0.74), however, the rate of ischemic stroke was increased (OR 1.14, p <0.001). Those in the high VTE risk group who had metastatic disease were at elevated risk for MI (OR 1.18, p<0.001) and even higher risk for ischemic stroke (OR 2.36, p<0.001).
Conclusions: Certain cancer types are associated with increased risk of both venous and arterial thrombosis. This risk is further increased by the presence of metastatic disease.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 10:45 a.m.-10:55 a.m.
Session Title: Highlights in Vascular Medicine Research
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1139M-09
- 2017 American College of Cardiology Foundation