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Background: Whether genetic factors influence growth patterns of abdominal aortic aneurysms (AAA) is unknown.
Methods: We studied 486 patients, who had ≥ 3 pre-operative measures for AAA size and available high-density genotyping information in the Mayo clinic Vascular Disease Biorepository. We classified patients as having early (EA, n = 268) vs. late-accelerated (LA, n = 220) growth pattern according to individual growth curves. Clinical information was ascertained from electronic health records. Genetic variants for AAA were selected from genome-wide association study catalog with a p ≤ 10E-5 and known functional variants from candidate gene studies.
Results: AAA expansion was faster in EA than LA group (p < 0.01). In patients who underwent AAA repair (n = 234), the odds ratio of EA vs LA pattern for re-intervention was 2.75 (95% CI: 1.25-6.47) independent of potential confounders (Table). The associations of clinical variables with AAA expansion were not differed by the pattern (Table, p for interaction > 0.05). Of 17 candidate genetic variants, 8 were associated with faster expansion and 3 associated with expansion differed by growth pattern (Table).
Conclusions: We identified two distinct growth patterns of AAA with different aneurysm behavior. EA was associated with increased risk of re-intervention and faster expansion than LA pattern. Genetic predisposition to AAA contributes to AAA expansion and susceptibility loci differently associated with growth pattern.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-3:55 p.m.
Session Title: Advancing Our Understanding of Aortic Disease
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1267M-03
- 2017 American College of Cardiology Foundation