Author + information
- Evangelos Oikonomou,
- Evgenia Bourouki,
- Georgia Siasou,
- Gerasimos Siasos,
- Marilita Moschos,
- Nikolaos Gouliopoulos,
- Theodore Paraskevopoulos,
- Georgia Vogiatzi,
- Sotirios Tsalamandris,
- George-Angelo Papamikroulis,
- Alexis Antonopoulos and
- Dimitris Tousoulis
Background: Primary open-angle glaucoma (POAG) is one of the most prevalent causes of irreversible blindness and is associated with endothelial dysfunction and arterial stiffness. Pseudoexfoliative glaucoma (PEG) is another type of glaucoma observed in pseudoexfoliation syndrome. It is characterized by the deposition of pseudoexfoliative material in several tissues and organs. We investigated the association of endothelial dysfunction and arterial wall elastic properties with systemic inflammation in patients with Pseudoexfoliative Glaucoma.
Methods: In this study we enrolled 25 subjects with PEG, 25 subjects with POAG and 25 control subjects. Endothelial function was evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. Growth differentiation factor-15 (GDF-15) and intercellular adhesion molecule 1 (ICAM1) were also measured to evaluate systemic inflammatory status and cell apoptosis.
Results: Between the three study groups (control, POAG, PEG) there was no difference in age (59±9y vs. 60±6y vs. 65±13y, p=0.96) or prevalence of male sex (70% vs. 68% vs. 67%, p=0.55). Importantly, comparing control, POAF and PEG subjects there was a linear impairment of FMD (9.76±3.1% vs. 7.15±2.85% vs. 5.77±3.34%, p=0.001) and PWV (7.68±1.34m/sec vs. 8.11±1.84m/sec vs. 8.97±1/82m/sec, p=0.075) in parallel with a stepwise increase in GDF-15 [0.736 (0.568, 0.841) ng/L vs. 0.968 (0.757, 1.097) ng/L vs. 1.299 (0.8, 2.233) ng/L, p=0.001] and sICAM levels [114.65 (80.88, 165.43) μg/ml vs. 121.88 (89.75, 194.11) μg/ml vs. 194.44 (160.53, 226.45) μg/ml, p=0.012] between control, POAG and PEG subjects.
Conclusions: Patients with pseudoexfoliative glaucoma have impaired endothelial function, arterial stiffness and inflammatory status compared to patients with primary open-angle glaucoma and control subjects. These findings shed light on the pathophysiology of pseudoexfoliative glaucoma and support the theory that pseudoexfoliative fibrils may precipitate systemic inflammatory response and apoptosis and may also accumulate and damage the arterial wall.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: MicroRNAs and Beyond in Vascular Medicine
Abstract Category: 38. Vascular Medicine: Basic
Presentation Number: 1127-359
- 2017 American College of Cardiology Foundation