Author + information
- Jacqueline Denysiak,
- David Krummen,
- Hee-Kyung Chun,
- Taelor Getz,
- Meher N. Haque,
- Avinash Toomu,
- Gregory Feld,
- Jonathan Hsu and
- Lori Daniels
Background: Catheter ablation is increasingly used for patients with symptomatic atrial fibrillation (AF) and atrial flutter (AFL). However, outcomes for female patients lag those for males in large, randomized trials. We hypothesized that females may present to ablation with more advanced structural remodeling than men.
Methods: We enrolled consecutive patients with AF and/or AFL at a tertiary medical center. Plasma ST2 (Critical Diagnostics) levels were measured prior to their clinically indicated pulmonary vein isolation and/or AFL ablation procedure. Historical, ECG, echocardiographic, and procedural data were recorded. Analyses were performed using SPSS; 2-sided p<0.05 was considered statistically significant.
Results: In 70 consecutive patients (mean age 63.4±15.6 years, 69% male), women had larger left atrial (LA) size than men, despite lower ST2 levels (Table). In men but not in women, higher ST2 levels were associated with larger LA diameter (r = 0.34, p=0.03; p for interaction = 0.015) and LA volume index (LAVI, r=0.34, p=0.04). Higher ST2 levels were also associated with longer procedure times, independent of age and repeat ablation status, in men but not women (beta = 0.40, p=0.035, p for interaction = 0.02).
Conclusions: Female patients present with greater structural remodeling than men, despite lower ST2 levels. Such patients may represent a distinct phenotype of AF, requiring alternative mapping and ablation techniques to improve outcomes; additional study is required.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: AF Miscellaneous and Surgical Issues
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1236-093
- 2017 American College of Cardiology Foundation