Author + information
- Walter S. Speidl,
- Konstantin Krychtiuk,
- Max Lenz,
- Stefan Kastl,
- Johann Wojta and
- Gottfried Heinz
Background: Growth differentiation factor (GDF)-15 levels are associated with all-cause mortality in patients with acute coronary syndromes, however data in patients with acute heart failure are conflicting. The aim of this study was to investigate the predictive value of GDF-15 in patients with severe acute heart failure (AHF) or cardiogenic shock that require admission to an intensive care unit.
Methods: We included 90 consecutive patients with AHF or cardiogenic shock admitted to a cardiac ICU. GDF-15 at admission was measured by ELISA and patients were followed for 30 days.
Results: Mean age of patients was 62.1 ± 16.0 and 76.7% of patients were male. Median NT-proBNP levels were markedly increased (4986 IQR 1525 – 23842 pg/mL). 30-day mortality was 35.6%. In non-survivors GDF-15 was increased to 7119.5 IQR 3816.2 – 10168.2 ng/mL as compared to 2719.7 IQR 1472.9 – 7099.9 ng/mL (p<0.001). Patients in the third tertile of GDF-15 had an 5.1-fold increased risk of death (p<0.005) independently of demographics, NT-proBNP and vasopressor use. Interestingly, GDF-15 and NT-proBNP showed additive prognostic value. When patients were stratified according to the median of NT-proBNP and GDF-15, those with both GDF-15 and NT-proBNP levels above the median had the highest risk of dying (HR 8.5, p<0.005).
Conclusions: GDF-15 is a strong predictor of mortality in patients with severe acute heart failure or cardiogenic shock that require admission to a cardiac ICU and adds additional prognostic value to NT-proBNP levels.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Making Progress in Understanding Heart Failure
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1123-295
- 2017 American College of Cardiology Foundation