Author + information
- Veronika Sanin,
- Vanessa Pfetsch,
- Andrea Jaensch,
- Dhayana Dallmeier,
- Ute Mons,
- Hermann Brenner,
- Wolfgang Koenig,
- Dietrich Rothenbacher and
- Deutsches Herzzentrum München
Background: Soluble (s) ST2, a member of the interleukin-1 family, has been suggested to play a role in cardiac remodelling and inflammatory signalling. We assessed the long-term predictive value of sST2 in patients with stable coronary heart disease (CHD), simultaneously controlling for a large number of potential confounders.
Methods: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1,081 patients. The Cox-proportional hazards model was used to determine the prognostic value of sST2 on a combined cardiovascular disease (CVD) endpoint, on cardiovascular death, and on total mortality after adjustment for covariates.
Results: The median sST2 level was 28.9 ng/mL (IQR 23.8, 35.1). During a median follow-up of 12.3 years, 272 patients experienced a fatal- or non-fatal subsequent CVD event and 260 patients died (incidence rate per 1000 patient years 26.1 and 20.6, respectively). There was no statistically significant association with the combined endpoint of non-fatal and fatal CVD events when the top quartile (Q4) of sST2 concentration was compared to the bottom quartile (Q1). However, a relationship was seen with CVD mortality even after multivariable adjustments including clinical risk variables (HR 1.65; 95% CI 1.02-2.86), but not in a fully adjusted model. The sST2 concentration was still significantly associated with total mortality in the fully adjusted model including clinical variables and cystatin C based estimated glomerular filtration rate, NT-proBNP, hsCRP and hs-TnI with an HR of 1.48 (95% CI 1.03-2.13) comparing Q4 vs Q1.
Conclusions: Elevated levels of sST2 concentration in stable CHD patients may independently predict short and long-term risk for fatal CVD events and total mortality but not for non-fatal CVD events.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Biomarkers and Targets for Ischemic Heart Disease
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1164-299
- 2017 American College of Cardiology Foundation