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To compare the effect and safety of domestic biodegradable polymer sirolimus-eluting stents and durable polymer sirolimus-eluting stents in interventional therapeutic of patients with coronary heart disease.
A cohort of 2950 consecutive patients with coronary arterial disease who underwent drug eluting stents implantation was carried out. The patients were divided into the biodegradable polymer group (n=1520), durable polymer group (n=1430). Gender data was matched for correction by using propensity score matching method. The incidence of main adverse cardiac event (MACE) (including cardiac death, myocardial infarction and target vessel revascularization) and stent thrombosis (ST) were followed up within one year.
Two groups were similar in main baseline clinical information and major angiography characteristics after matching. The results showed that the two groups of patients with cardiogenic death (1.75%VS1.75%, P=1.0), myocardial infarction (3.63% VS 3.9%, P=0.7), target vessel revascularization (2.22%VS2.62%, P=0.47) and MACE (6.72% VS 7.26%,P = 0.57); stent thrombosis (1.2% VS 1.01%,P=0.18) were all no significant difference.
The recent efficacy and safety of domestic biodegradable polymer sirolimus-eluting stents and durable polymer sirolimus-eluting stents in the treatment of coronary artery disease are similar, its long-term effect needs further study.