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To evaluate whether elderly (65y or elder) is an independent risk factor of net clinical adverse events and cerebrovascular events(NACCE) in patients implanted with Drug-eluting stents with biodegradable polymer (BP-DES).
In the I-LOVE-IT 2 Trial, 1829 patients were implanted with BP-DES. The primary end point of this research was target lesion failure(TLF) rate on 12 months and the secondary end point was NACCE including all-cause death, myocardial infarction, stroke and major bleeding(BARC 3-5).
There were 627 patients with age>65 and 1202 at age<65. The Baseline conditions of the two groups of patients were significantly different in BMI, diabetes, hypertension, hyperlipidemia, family history of coronary heart disease, smoking history, history of previous stroke, history of peripheral vascular disease and stable angina pectoris. There were also marked difference on NACCE (10% vs 5.2%, P < 0.01), all-cause mortality (2.7% vs 0.7%, P < 0.01), stent thrombosis (1.9% vs 0.5%, P < 0.01) and stroke (2.2% vs 0.8%, P=0.01) between Elderly group and non elderly group. Taking NACCE, all-cause death, stent thrombosis and stroke as a reasonable variable and using Cox regression model to make multiple factors regression analysis, which reveals that elderly (65y or elder) is the independent risk factor of NACCE, all-cause death, stent thrombosis and stroke, respectively.
Elderly is an independent risk factor of 12-month NACCE in patients implanted with BP-DES.