Author + information
- Yubi Lin1,2,
- Yumei Xue1,
- Siqi He2,1,
- Ruiling Feng2,1,
- Zhe Xu3,
- Wanqun Chen4,
- Zifeng Huang2,1,
- Yang Liu1,
- Qianhuan Zhang1,
- Bin Zhang1,
- Kejian Wang5 and
- Shulin Wu1
- 1Guangdong General Hospital and The First Clinical College Affiliated to Medical School, South China University of Technology;, Guangdong Cardiovascular Institute;, Guangdong Provincial Key Laboratory of South China structural Heart Disease;, Guangdong Academy of Medical Sciences, Guangzhou, P.R. China
- 2The First Affiliated Hospital of Jinan University, Guangzhou, P.R. China
- 3Division of Cardiac Surgery, First Affiliated Hospital of Sun-Yat-sen University, Guangzhou, P.R. China
- 4Department of Biochemistry and Molecular Biology, Medical College, Jinan University, Guangzhou, P.R. China
- 5Lin He’s Academician Workstation of New Medicine and Clinical Translation at The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, P.R. China
Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015.
These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14–1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33–1.59–, P =4.27×10-5). We further explored previously published evidences and found 821 human genes directly or indirectly interacting with digoxin. Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia.
Taken together, our retrospective analysis demonstrated the significant association between digoxin treatment and anemia adverse reaction, which should be seriously considered in clinical practice.
Functional enrichment analysis on digoxin-related genes warranted subsequent research on the underlying toxicological mechanisms.