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Previous studies have demonstrated conflicting results on the relationship between siesta and coronary artery disease (CAD). The aim of this project was to clarify whether siesta is associated with the incidence of CAD.
Between January 1994 and November 2011, 4993 patients were recruited for a prospective observational study (ClinicalTrials.gov Identifier: NCT00005275). The initial diagnostic approach for CAD includes syndrome, echocardiography and electrocardiogram. After the initial evaluation, stress testing, CT angiography or coronary angiogram was performed for further verification in patients with atypical symptoms according to the guideline. Subjects were interviewed on number of siesta every week and the average duration of their siesta in the baseline examination. Multivariate logistic regression analysis was used to explore the relationship between siesta and the incidence of CAD.
In our study, there were 787 patients with CAD (69.8±9.8 years) and 4206 patients without CAD (62.8±11.0 years). Distributions of CAD and non-CAD were significantly different between the siesta group and non-siesta group (21.0% vs. 14.3%; p<0.001). After adjusting for potential confounding factors, results of multivariate logistic regression showed that siesta (OR=1.277; 95% CI=1.068-1.526; p=0.007), age (OR=1.061; 95% CI=1.053-1.069; p<0.001) and number of siesta every week (OR=1.070; 95% CI=1.050-1.091; p<0.001) were associated with the incidence of CAD.
These results suggest that siesta may play a disadvantageous role in the incidence of CAD. However, further studies are needed to verify our findings in other populations and investigate the underlying mechanisms.