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To analysis of clinical and hemodynamic parameters in cohort of patients with T2DM and chronic heart failure (CHF).
Included 134 patients with CHF of both sexes hospitalized in the cardiology department of Moscow region. All patients were divided into two group: group I (patients with CHF and T2DM, n = 66, 61.8 ± 7.2 years, 28 men, 38 women), and group II (patients with CHF without diabetes, n = 68; 62.3 ± 7.7 years, 33 men, 35 women). The following were performed: assessment of the symptoms of the disease using the Clinical State Assessment Scale (SHOCS); ECG at rest in 12 standard leads; Transthoracic echocardiography; Laboratory blood tests; X-ray of the chest; Test with a 6-minute walk.
Patients with CHF and T2DM had a relatively high functional class of HF, a severity of symptoms (according to SHOCS 13.7 ± 2.2 points against 11.1 ± 2.2 points, p <0.05), as well as more pronounced morphofunctional changes: a significant decrease in LVEF by 5.5%, as well as an increase in the time of delay in the blood flow of early diastolic filling, accompanied by a decrease in the E/A ratio. The revealed features of the clinical course were accompanied by impaired biochemical indices. The study of the anamnesis of patients with CHF and diabetes in this cohort allowed to reveal insufficient control (less than 80%) of glycemia among patients with diabetes and CHF, despite the long-term course of the violation of carbohydrate metabolism.
The results of the study demonstrate the negative nature of the contribution of diabetes mellitus during CHF, both ischemic and non-ischemic genesis.