Author + information
- 1Department of Cardiology, Peking University People’s Hospital, Beijing, China
- 2Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, China
- 3Center for Cardiovascular Translational Research, Peking University People’ s Hospital, Beijing, China
T13254C polymorphism (rs1613662) within the glycoprotein VI gene was associated with higher density of glycoprotein VI on platelets, thus increasing the likelihood to develop acute coronary syndrome (ACS). There have been conflicting opinions regarding the correlation of glycoprotein VI gene T13254C genotype with ACS risk, which prompted us to conduct a meta-analysis to determine the elusive association.
PubMed, EMBASE and Web of Science were searched for pertinent reports. A total of 7 studies involving 2947 ACS cases and 2721 controls were analyzed in the present quantitative analysis.
No statistically significant association was found between glycoprotein VI T13254C polymorphism and ACS in the allele model (C vs. T, OR=1.03, 95%CI=0.93-1.15), homozygote model (CC vs. TT, OR=1.09, 95%CI=0.77-1.55), heterozygote model (CT vs. TT, OR=1.03, 95%CI=0.90-1.17), dominant model (CT+CC vs. TT, OR=1.04, 95%CI=0.91-1.17) and recessive model (CC vs. CT+TT, OR=1.08, 95%CI=0.76-1.53). In subgroup analysis stratified by race, significant association was found in neither Caucasians (allele model: OR=1.08, 95%CI=0.95-1.22; homozygote model: OR=1.23, 95%CI=0.81-1.87 ; heterozygote model: OR=1.07, 95%CI=0.92-1.24; dominant model: OR=1.08, 95%CI=0.94-1.25; recessive model: OR=1.21, 95%CI=0.80-1.83) nor non-caucasians(allele model: OR=0.90, 95%CI=0.72-1.13; homozygote model: OR=0.80, 95%CI=0.40-1.58 ; heterozygote model: OR=0.92, 95%CI=0.70-1.20; dominant model: OR=0.90, 95%CI=0.70-1.17; recessive model: OR=0.80, 95%CI=0.41-1.59). Sensitivity analysis and publication bias analysis revealed stable and statistically robust results.
In conclusion, this comprehensive meta-analysis on 7 studies showed no evidence supporting a causal association between glycoprotein VI T13254C SNP and ACS vulnerability. Larger population studies are urgently needed to validate our current findings.