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The study sought to assess whether catheter-based renal denervation (RDN) could prevent cardiac function deterioration early after myocardial infarction (MI).
Anterior MI was induced in 28 male Chinese mini-swines by transient balloon occlusion of left anterior descending coronary artery. Then the swines were randomly assigned to receive bilateral catheter-based RDN (RDN group, n=14) or sham-denervation (sham group, n=14). Both two groups were studied up to 8 weeks. All of the RDN procedures were performed by experienced operators strictly adhered to recommendations provided by the catheter manufacturer. Before and after the modeling and 8 weeks after the intervention, the cardiac function would be determined by measuring left ventricular ejection fraction (LVEF) with 2-D echocardiography and Cardiac Output (CO) with Swan-ganz catheter. Data from two group were compared using repeated measures ANOVA (rmANOVA).
Modeling process is optimal and the baseline characters were well adjusted as covariable using rmANOVA. Significant time x group interaction effects were detected with respect to LV end diastolic volume (EDV) and LVEF. EDV and LVEF increased more in RDN group than sham group after AMI (32.55±8.90 to 52.69±9.73 ml vs. 31.05±14.56 to 38.5±12.33 ml, P=0.015 for interaction; 53.06±11.11 to 60.47±9.30 % vs. 57.29±11.42 to 51.71±12.24 %, P=0.016 for interaction). Meanwhile heart rate tended to be lower and CO tended to be higher in RDN group but they both failed to show a significant benefit (122±21 to 101±33 bpm vs. 118±28 to 114±36 bpm, P=0.346 for interaction; 2.00±0.55 to 2.59±0.41 L/min*m2 vs. 1.98±0.50 to 2.19±0.72 L/min*m2, P=0.336 for interaction). There were no significant changes in left ventricle geometric patterns and diastolic function as well as the blood pressure.
Renal denervation shows significant improvements on cardiac function in acute myocardial infarction swine models induced by balloon occlusion, mainly due to the increase of EDV which suggests beneficial effects on ventricular remodeling.
ENDOVASCULAR: Hypertension Therapies and Renal Denervation