Author + information
- Received July 30, 2019
- Revision received October 16, 2019
- Accepted October 21, 2019
- Published online December 9, 2019.
- ↵∗Address for correspondence:
Dr. Mohamad Alkhouli, Department of Cardiovascular Medicine, Mayo Clinic School of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905.
• Ischemic stroke risk prediction is a cornerstone in the management of patients with atrial fibrillation.
• The paper reviews the evolution of these risk scores, discusses their strengths and limitations, and appraises the emerging risk assessment tools and their incremental utility.
• There is an unmet need for a comprehensive study incorporating various clinical, anatomic, and biophysiological risk factors to optimize our stroke prevention practices in patients with atrial fibrillation.
The last decade has witnessed remarkable advances in pharmacological and nonpharmacological strategies for stroke prevention in patients with atrial fibrillation. However, the currently available clinical stroke risk prediction models do not account for key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electrocardiographic markers) and other competing clinical risks. Hence, their ability to identify patients who will derive the most benefit from pharmacological and mechanical risk prevention strategies remain limited. In this paper, the authors review the current and evolving ischemic stroke risk prediction schemes in patients with nonvalvular atrial fibrillation, highlight the strengths and weaknesses of the models, and discuss the unmet needs in this field.
Both authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received July 30, 2019.
- Revision received October 16, 2019.
- Accepted October 21, 2019.
- 2019 American College of Cardiology Foundation
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