Author + information
- Aaron W. Aday,
- Meredith S. Duncan,
- Charles W. Alcorn,
- Quinn S. Wells,
- Joshua Beckman and
- Matthew S. Freiberg
There are no large national cohorts examining the incidence of peripheral artery disease (PAD) among participants previously tested for PAD by ankle-brachial index (ABI) at baseline. Such data are critical as prevalent PAD often goes unrecognized.
We analyzed 164,441 participants in the Veterans Affairs (VA) Birth Cohort, an observational, prospective cohort of veterans born between 1945-1965 who were free of PAD at baseline, based on a first recorded ABI 0.90-1.39. PAD incidence was defined as subsequent ABI <0.90. Follow-up ended at the minimum of PAD incidence, death, or September 30, 2017. Unadjusted PAD incidence rates were estimated by Poisson regression. Cox proportional hazards regression was used to estimate age- and multivariable-adjusted risk of PAD by sex, race, diabetes mellitus, and smoking status.
Participants had a mean age of 60 years, 96% were male, and 39% had a history of cardiovascular disease. During a median follow-up of 4.1 years, 8,861 participants developed incident PAD. Rates and risk of PAD differed significantly by sex, race, diabetes and smoking status (Table) with highest risk among men, White or African American participants, those with diabetes, and current smokers.
In the VA Birth Cohort, smokers and diabetics had the highest rates of incident PAD. The rates and risk of incident PAD were twice as high among men compared to women. In contrast, there was no increased risk of incident PAD among African Americans compared to Whites.
Moderated Poster Contributions
Valvular Heart Disease and Vascular Medicine Moderated Poster Theater, Posters, Hall A
Saturday, March 28, 2020, 12:30 p.m.-12:40 p.m.
Session Title: On the Cutting Edge in Peripheral Artery Disease
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1019-03
- 2020 American College of Cardiology Foundation