Author + information
- Damianos Kokkinidis,
- Stefanos Giannopoulos,
- Moosa Haider,
- Timothy Jordan,
- Anita Sarkar,
- Gagan Singh,
- Eric Secemsky,
- Jay S. Giri,
- Joshua Beckman and
- Ehrin J. Armstrong
Previous studies have shown that smoking cessation is associated with improved wound healing in diabetic ulcers, but there are few data for the association between active smoking and wound healing in critical limb ischemia (CLI).
CLI patients who underwent endovascular interventions were included. Smoking status was assessed at the time of the intervention comparing active to no active smoking and also during 6-, 9-, 12-month follow-up visits. A univariable and multivariable Cox regression analysis was conducted and Kaplan Meier (KM) survival curves were estimated.
In total, 264 patients (active smokers: n=41; not active smokers: n=223) and 553 lesions were included. Active smoking was associated with reduced rates of wound healing in the 6-month univariate cox regression analysis (HR for lack of wound healing: 4.54; 95% CI: 1.41 - 14.28; p = 0.012). Active smoking was also associated with reduced rates of wound healing in the 9-month univariable (HR for lack of wound healing: 2.32; 95% CI: 1.11- 4.76; p = 0.026) and multivariable analysis (HR for lack of wound healing: 9.09; 95% CI: 1.06 - 100.0; p=0.044).
Active smoking status at the time of intervention in CLI patients is associated with lower rates of complete wound healing during both 6- and 9-month follow-up. Active smoking was associated with on average a two-month delay in the median time to wound healing. These findings emphasize the importance of smoking cessation for patients with CLI
Moderated Poster Contributions
Valvular Heart Disease and Vascular Medicine Moderated Poster Theater, Posters, Hall A
Saturday, March 28, 2020, 12:45 p.m.-12:55 p.m.
Session Title: On the Cutting Edge in Peripheral Artery Disease
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1019-05
- 2020 American College of Cardiology Foundation