Author + information
- Jose Patricio Lopez,
- Patricio Lopez-Jaramillo,
- Paul A. Camacho,
- Darryl Leong,
- Sumathy Rangarajan and
- Salim Yusuf
Early identification with simple approaches is required to achieve a reduction in the burden of cardiovascular disease (CVD). The association of obesity/sarcopenia gives an additional risk to each of the factors independently. We aimed to establish if the relationship handgrip strength (HGS)/obesity is associated with CVD and could predict CVD.
This was a secondary analysis of the PURE Colombia cohort. Data were obtained from the PURE study, including 7,444 adults between 35 - 70 years. The association between waist circumference (WC), waist-hip ratio (WHR) and body mass index (BMI) with quartiles of HGS were analyzed. Subjects were divided into four groups (non-obese/non-sarcopenic, non-obese/sarcopenic, obese/non-sarcopenic and obese/sarcopenic) depending on the presence of obesity and sarcopenia (defined as HGS in quartile 1-3). The subjects were divided into three profiles depending on the definition of obesity by BMI, WC or WHR. Variables were constructed to analyze the association between the WC, WHR, BMI and HGS quartiles. Stratified analysis was performed for associations by age, sex, educative status, and smoking.
The average age was 58.7 ± 5.68 for women and 59.1 ± 5.89 for men. 3456 were over 50 years old. 2192 (63.4%) were women. Subjects with obesity and low HGS have a higher risk for the studied outcomes compared to non-obese subjects and in the Q4 of HGS. In the three profiles, the subjects with sarcopenic - obesity were more at risk for hypertension RR 1.92 [1.70 - 2.17], diabetes RR 3.41 [2.41-4.81] and CVD RR 2.45 [1.71- 3.51] compared to subjects with only obesity or sarcopenia only. The use of the relationship between WC or WHR/ HGS was an adequate predictor of the presence of metabolic alterations and cardiovascular events. The effect was stable when stratifying by age and sex.
Obesity, mainly abdominal obesity, together with muscle function or the relation fat/muscle is a useful tool for predicting CVD, having a summative effect and greater implication than obesity or sarcopenia alone. Thus, the global management and prevention of CVD should include both the control of excess adiposity and maintenance of adequate/high levels of muscle strength
Posters Hall_Hall A
Saturday, March 28, 2020, 10:00 a.m.-10:45 a.m.
Session Title: ACC International Conferences Best Posters
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1136-416
- 2020 American College of Cardiology Foundation