Author + information
- Yaodan Liang,
- Qian Liu,
- Minghui Du,
- Simin Yao,
- Peipei Zheng,
- Yuhao Wan,
- Ning Sun,
- Jiefu Yang,
- Jianping Cai and
- Hua Wang
The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGsn) are recognized markers of RNA and DNA oxidative damage respectively. Both of them have not been explored in frailty.
A total of 508 elderly patients with cardiovascular disease (mean age 75.0±6.45years, 50.8% males) were enrolled. Frailty was assessed by Fried phenotype. The concentrations of 8-oxoGsn and 8-oxodGsn in urine were measured by improved ultra-high-performance liquid chromatography-mass spectrometry. Urinary creatinine (Cre) was tested to correct 8-oxoGsn and 8-oxodGsn.
According to the score of Fried phenotype, the robust, pre-frail, and frail percentage of these subjects were 20.5%, 53.9%, and 25.6% respectively. 8-oxoGsn/Cre (P<0.001) showed the significant difference among these three groups, but 8-oxodGsn/Cre (P=0.600) showed no difference. By using the univariable and multivariable Logistic regression, we found 8-oxoGsn/Cre[Odds Ratio (OR)=1.179, P=0.019] was independently associated with the frailty after balancing age and other significant variables.
The urinary 8-oxoGsn, as a recognized marker of RNA oxidative stress, is associated with frailty independently in elderly patients with cardiovascular disease. However, DNA oxidative stress shows no obvious correlation with frailty.
Posters Hall_Hall A
Saturday, March 28, 2020, 12:30 p.m.-1:15 p.m.
Session Title: Spotlight on Special Topics: Global Cardiovascular Health 2
Abstract Category: 43. Spotlight on Special Topics: Global Cardiovascular Health
Presentation Number: 1173-271
- 2020 American College of Cardiology Foundation