Author + information
- Pamela Piña Santana,
- Amparo Taveras,
- Amir Khan,
- Victor Bueno,
- Luis Cuello,
- Santiago Collado,
- Ann Mauer,
- Justin Coyle,
- Nishit Shah,
- Sorin Danciu and
- Cesar Herrera
Little is known about the characteristics of cardio-oncology (CO) patients, cancer therapy-induced cardiotoxicity (CTx) and guidelines-directed interventions in Latin America; analysis of CO services may clarify the links between ethnicity and socioeconomic status in this field.
We compared patients’ phenotypes, adherence to American Society of Clinical Oncology Guidelines and patterns of CTx between two similar CO services of tertiary care centers in the Dominican Republic (DR) and the US Midwest. Subjects being considered for or treated with potentially cardiotoxic drugs were included.
597 consecutive pts., 330 (55%) from DR and 267 (45%) from US were studied. DR vs. US X age 55± 13/52 ± 13 yrs.; female 77%/87% (p<0.001); breast cancer 57%/73% (p<0.01); treated with anthracyclines + taxanes 42%/37%; monoclonal antibodies + taxanes or platins 18%/32% (p<0.01). CTx DR vs. US occurred in 15%/7% (p=0.001), multivariate logistic regression (OR 2.24; 95% CI, 1.28-3.91; p<0.005) did not identify age >60, HTN, DM, BMI, tobacco or chemotherapy as predictors of CTx. Adherence to Guidelines shown.
Compared with the US, Caribbean cancer pts. have similar rates of CV risk factors but higher likelihood of developing drug-induced LV dysfunction. Programs’ compliance with guidelines was equivalent. These findings underline the relevance of CO services in nations with limited resources and high CV risk. Further research is needed to ascertain regional variations of CTx.
Posters Hall_Hall A
Saturday, March 28, 2020, 12:30 p.m.-1:15 p.m.
Session Title: Spotlight on Special Topics: Global Cardiovascular Health 2
Abstract Category: 43. Spotlight on Special Topics: Global Cardiovascular Health
Presentation Number: 1173-272
- 2020 American College of Cardiology Foundation